本公司经销CD337/NKp30/NCR3，细胞毒性受体NK-p30抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD337/NKp30/NCR3细胞毒性受体NK-p30抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2418R
英文名称：Anti-CD337/NKp30/NCR3
中文名称：细胞毒性受体NK-p30抗体
其他名称：Natural killer cell p30-related protein; natural cytotoxicity triggering receptor 3; 1C7; CD337; LY117; MALS; NKp30; NK receptor 1c7; 1c7 protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 22kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat
产品介绍：NCR3 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer （NK） cells to mediate tumor cell lysis. It is a member of the Ig superfamily ａnd may cooperate with NKp46 ａnd NKp44 in the induction of cytotoxicity against a variety of target cells ａnd is selectively expressed by all NK cells, both freshly isolated ａnd cultured in IL2, thus representing an optimal marker for NK cell identification. Similar to NKp46 ａnd CD16, NKp30 associated with CD3 zeta chains becomes tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type ａnd by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion. It is selectively expressed by all resting ａnd activated NK cells ａnd weakly expressed in spleen.Subunit : Homodimer in the unliganted form. Interacts with CD3Z. Interacts with ａnd is activated by binding to B7H6. Interacts with ａnd is activated by binding to BAG6.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Selectively expressed by all resting ａnd activated NK cells ａnd weakly expressed in spleen.Similarity : Belongs to the natural cytotoxicity receptor （NCR） family. Contains 1 Ig-like （immunoglobulin-like） domain.细胞毒性受体家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。