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CD336/NKp44/NCR2细胞毒性受体NK-p44抗体
点击次数:201发布时间:2012/12/5 10:37:24
更新日期:2024/9/5 14:43:01
所 在 地:中国大陆
产品型号:BY-2420R
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详细内容
货号:BY-2420R
英文名称:Anti-CD336/NKp44/NCR2
中文名称:细胞毒性受体NK-p44抗体
其他名称:Natural killer cell p44-related protein; CD336; CD336 antigen; LY95; Lymphocyte antigen 95 homolog; Natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; NK cell activating receptor; NK p44; NKp44.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 30kDa
纯化方法:affinity purified by Protein A
交叉反应:hu
产品介绍:NCR2 (NKp44) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. NCR2 displays a single extracellular Ig-like V domain and a transmembrane portion containing the charged residue (Lysine), likely involved in the association with KARAP/DAP12 molecules. Gene coding for NCR2 maps on human chromosome 6p21.1Subunit : Interacts with TYROBP/DAP12.Subcellular Location : Cell membrane; Single-pass type I membrane protein (Potential).Tissue Specificity : Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.Similarity : Belongs to the natural cytotoxicity receptor (NCR) family.Contains 1 Ig-like (immunoglobulin-like) domain.细胞毒性受体家族(NCRs)主要有:NKp46、NKp44和NKp30,其中NKp46和NKp30表达于所有静止和活化的NK细胞,而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合(交联)引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素,而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。产品图片Antigen: bs-2420P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.