产品展示
C17orf4917号染色体开放阅读框49抗体
点击次数：194发布时间：2012/12/5 10:42:18
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-9640R
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详细内容
货号：BY-9640R
英文名称：Anti-C17orf49
中文名称：17号染色体开放阅读框49抗体
其他名称：Bap18;BAP18_HUMAN;BPTF-associated protein of 18 kDa;Chromatin complexes subunit BAP18;Chromosome 17 open reading frame 49;Hypothetical protein LOC124944;MGC49942;Uncharacterized potential DNA binding protein C17orf49.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 18kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, zebrafish
产品介绍：C17orf49 is a 172 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 ａnd BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth ａnd Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer ａnd predisposition to cancers of the ovary, colon, prostate gland ａnd fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural ａnd epidermal lesions, ａnd dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome ａnd Canavan disease are also associated with chromosome 17.Subcellular Location : Nucleus.
