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CTCF转录阻抑蛋白CTCF抗体
点击次数：219发布时间：2012/12/5 10:50:28
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3778R
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详细内容
货号：BY-3778R
英文名称：Anti-CTCF
中文名称：转录阻抑蛋白CTCF抗体
其他名称：11 zinc finger protein; 11 zinc finger transcriptional repressor; CCCTC binding factor （zinc finger protein）; CCCTC binding factor; CTCFL paralog; Transcriptional repressor CTCF.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog, cow
产品介绍：CTCF （CCCTC-binding factor） is a highly conserved zinc finger protein that has been implicated in playing a role in a wide range of regulatory functions, including transcriptional activation/repression, insulation, imprinting, ａnd X chromosome inactivation. A general role for CTCF in the global organisation of chromatin architecture has been proposed. It has been suggested that CTCF is involved, in a heritable manner, in the interplay between DNA methylation, higher-order chromatin structure, ａnd lineage-specific gene expression.Subunit : Interacts with CHD8.Subcellular Location : nucleoplasm. Chromosome.Tissue Specificity : Ubiquitous. Absent in primary spermatocytes.Similarity : Belongs to the CTCF zinc-finger protein family. Contains 11 C2H2-type zinc fingers.CTCF是一种结构保守、功能多样的锌指蛋白。通过不同锌指的组合，识别不同的DNA序列，并且通过自身形成多聚体或与其它蛋白相互作用、与亚细胞核结构共定位等多种方式，在基因活化与沉默、基因印记、X-染色体失活以及基因组核内空间组织等不同生理过程中发挥关键作用。CTCF在细胞生长与增殖、系统发生以及肿瘤发生等方面都有着重要的作用。
