本公司经销CD71/TFR/Transferrin receptor，转铁蛋白受体抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD71/TFR/Transferrin receptor转铁蛋白受体抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0988R
英文名称：Anti-CD71/TFR/Transferrin receptor
中文名称：转铁蛋白受体抗体
其他名称：CD 71; CD71; CD71 antigen; p90; T9; TFR 1; TFR; TFR1; TFRC; TR; Transferrin receptor （p90 CD71）; Transferrin Receptor Protein 1; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; Transferrin receptor protein 1, serum form; TRFR.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 74/85kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH ａnd the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes ａnd the nervous system （By similarity）. Useful in studies of dividing haematopoietic ａnd tumour cell populations, ａnd metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells ａnd most proliferating cells in vitro.Subunit : Homodimer; disulfide-linked. Binds one transferrin molecule per subunit.Interacts with SH3BP4.Subcellular Location : Cell membraneSimilarity : Belongs to the peptidase M28 family. M28B subfamily.转铁蛋白及转铁蛋白受体（TfnrR）是机体铁代谢中的重要因子，铁是细胞生长增殖、代谢的必需元素,转铁蛋白受体（TfR）介导的胞吞作用是细胞摄取铁的主要途径。肿瘤细胞因增殖生长旺盛,对铁的需求高,所以肿瘤细胞有比正常细胞更多的转铁蛋白受体的表达。产品图片Antigen: bs-0988P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.