产品展示
Caspase-12半胱胺酸蛋白酶蛋白-12抗体
点击次数：281发布时间：2012/12/5 10:56:38
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-0967R
优质供应
详细内容
货号：BY-0967R
英文名称：Anti-Caspase-12
中文名称：半胱胺酸蛋白酶蛋白-12抗体
其他名称：UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; Caspase12; inactive caspase-12.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Three distinct signaling pathways lead to apoptosis. The death receptor ａnd mitochondrion pathways are the two mains, which involve respectively caspase-8 ａnd caspase-9. The endoplasmic reticulum stress is the third apoptotic pathway ａnd involves caspase-12. Localized to the ER but not to cytoplasm or mitochondria, caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer＇s disease including g-secretase presenilin ａnd b-amyloid precursor protein （APP）. Caspase-12 mediates ER stress-induced apoptosis as well as cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues.Tissue Specificity : Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus ａnd testis.Similarity : Belongs to the peptidase C14A family.Contains 1 CARD domain.ASPASE-12是caspase家族成员，是存在于内质网上的促凋亡因子，内质网应激早期可通过GRP（glucose-regulated protein，GRP）的表达增多来保护细胞；CASPASE-12是内质网细胞关键介导因子，caspase-12还是caspase-1的抑制剂。产品图片Antigen: bs-0967P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti- Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
