本公司经销CK17/Cytokeratin 17，细胞角蛋白17抗体，克隆类型为polyclonal，宿主来源是Rabbit，CK17/Cytokeratin 17细胞角蛋白17抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1431R
英文名称：Anti-CK17/Cytokeratin 17
中文名称：细胞角蛋白17抗体
其他名称：39.1; CK 17; Cytokeratin17; K17; Keratin 17; Keratin type I cytoskeletal 17; Keratin17; KRT 17; KRT17; KRT17 protein; PC; PC2; PCHC1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, hrs, shp
产品介绍：May play a role in the formation ａnd maintenance of various skin appendages, specifically in determining shape ａnd orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen （growth） state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis ａnd epithelial cell growth through binding to the adapter protein SFN ａnd by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia ａnd therefore indicative of a certain type of epithelial ＇stem cells＇. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells ａnd hence causing their proliferation （By similarity）. [SUBUNIT] Heterodimer of a type I ａnd a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD ａnd SFN. Belongs to the intermediate filament family.Function : May play a role in the formation ａnd maintenance of various skin appendages, specifically in determining shape ａnd orientation of hair. May be a marker of basal cell differentiation in complex epithelia ａnd therefore indicative of a certain type of epithelial ＇stem cells＇. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells ａnd hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen （growth） state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis ａnd epithelial cell growth through binding to the adapter protein SFN ａnd by stimulating Akt/mTOR pathway. Involved in tissue repai.Subunit : Heterodimer of a type I ａnd a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD ａnd SFN.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed in the outer root sheath ａnd medulla region of hair follicle specifically from eyebrow ａnd beard, digital pulp, nail matrix ａnd nail bed epithelium, mucosal stratified squamous epithelia ａnd in basal cells of oral epithelium, palmoplantar epidermis ａnd sweat ａnd mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland ａnd in exocervix （at protein level）.DISEASE : Defects in KRT17 are a cause of pachyonychia congenital type 2 （PC2） [MIM:167210]; also known as pachyonychia congenital Jackson-Lawler type. PC2 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis （thickening ａnd increase in curvature of the nail）, palmoplantar keratoderma ａnd hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow ａnd body hair, ａnd by the presence of natal teeth.Defects in KRT17 are a cause of steatocystoma multiplex （SM） [MIM:184500]. SM is a disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, ａnd thighs.Note=KRT16 ａnd KRT17 are coexpressed only in pathological situations such as metaplasias ａnd carcinomas of the uterine cervix ａnd in psoriasis vulgaris.Similarity : Belongs to the intermediate filament family.结构蛋白（Structural Proteins）常用于肿瘤细胞的分化、增殖及转移方面的研究。