产品展示
Phospho-Cofilin(Ser3)磷酸化丝切蛋白抗体
点击次数：253发布时间：2012/12/5 10:58:08
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3099R
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详细内容
货号：BY-3099R
英文名称：Anti-Phospho-Cofilin（Ser3）
中文名称：磷酸化丝切蛋白抗体
其他名称：18 kDa phosphoprotein; CFL 1; CFL; CFL1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; p18.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 18kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, shp, cow
产品介绍：Cofilin is a small phosphoinositide sensitive, actin binding protein capable of depolymerizing actin filaments in vitro. Under certain conditions, it fragments the filaments ａnd accelerates actin subunit dissociation from their "pointed’ （minus） ends. Cofilin binds stoichiometrically to monomeric G-actin ａnd to actin protomers in filaments in an apparent pH-dependent, Ca2+- independent manner. Cofilin intercalates between longitudinally associated actin monomers within the filament ａnd distorts its helical twist. Cofilin is ubiquitous in tissues of eukaryotes ａnd is especially abundant in neuronal tissues. It is essential for viability ａnd is important for many cellular processes involving actin remodeling such as motility at the leading edge of cells, polarized cell growth, endocytosis, phagocytosis, cellular activation, cytokinesis, ａnd pathogen intracellular motility. Subunit : Can bind G- ａnd F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear ａnd cytoplasmic actin rods.Subcellular Location : Nucleus matrix. Cytoplasm, cytoskeleton.Tissue Specificity : Widely distributed in various tissues.Similarity : Belongs to the actin-binding proteins ADF family. Contains 1 ADF-H domain.丝切蛋白（cofilin）是细胞骨架塑形的重要调节因素,其主要功能是分解肌动蛋白微丝和增加肌动蛋白单体从肌动蛋白微丝的末端解离的速度,从而促进肌动蛋白微丝的循环,是目前为止已发现的肌动蛋白结合蛋白家族中能够改变肌动蛋白微丝扭曲结构的蛋白.
