产品展示
CNOT2细胞表面趋化因子受体4相关蛋白2抗体
点击次数：167发布时间：2012/12/5 11:00:14
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-9383R
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详细内容
货号：BY-9383R
英文名称：Anti-CNOT2
中文名称：细胞表面趋化因子受体4相关蛋白2抗体
其他名称：CCR4 associated factor 2; CCR4 NOT transcription complex subunit 2; CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CDC36; CNOT2; CNOT2_HUMAN; HSPC131; MSTP046; Negative regulator of transcription 2; NOT2 （negative regulator of transcription 2 yeast） homolog; NOT2; NOT2H.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 59kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs
产品介绍：CNOT2 （CCR4-NOT transcription complex subunit 2） is a ubiquitous protein encoded by the human gene CNOT2. CNOT2 belongs to the CNOT2/3/5 family ａnd is part of the CCR4-NOT complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits （e.g. CNOT1, CNOT2） are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. Increased expression of the CNOT2 subunit acts to strongly repress transcription by RNA polymerase II. This repressive effect is mediated by a conserved NOT-Box, which is located at the C-terminus of CNOT2 proteins. Repression by the NOT-Box is sensitive to treatment with the histone deacetylase （HDAC） inhibitor trichostatin A.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung ａnd peripheral blood leukocytes.
