本公司经销COMMD10，铜代谢结构域蛋白10抗体，克隆类型为polyclonal，宿主来源是Rabbit，COMMD10铜代谢结构域蛋白10抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-8181R
英文名称：Anti-COMMD10
中文名称：铜代谢结构域蛋白10抗体
其他名称：COMM domain containing 10; COMMD 10; FLJ11285; HGNC:30201; HSPC305; PTD002.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb
产品介绍：COMMD or COMM is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes ａnd were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved ａnd unique motif termed the COMM （copper metabolism gene MURR1） domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms ａnd define a novel family of structural ａnd functional homologs of MURR1. The prototype of this family, MURR1/COMMD1, suppresses NFkB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs; rather, it functions in the nucleus by affecting the association of NF-kappaB with chromatin.Function : Promotes ubiquitination of NF-kappa-B subunit RELA ａnd its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.Subunit : Monomer ａnd homodimer. Interacts （via COMM domain） with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 ａnd COMMD10 （via COMM domain）. Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 ａnd RBX1. Interacts directly with SOCS1 ａnd CUL2. Interacts directly the N-terminal region of ATP7B. Interacts with CCS, CDKN2A, RELA ａnd NFKBIB. Identified in a complex with NF-kappa-B. Interacts with CLU.Subcellular Location : Nucleus. Cytoplasm. Note=Shuttles between nucleus ａnd cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.Tissue Specificity : Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney ａnd placenta.Post-translational modifications : Ubiquitinated; undergoes both ＇Lys-63＇- ａnd ＇Lys-48＇-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation.Similarity : Contains 1 COMM domain.