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CD168/RHAMM透明质酸介导细胞游走受体抗体
点击次数：300发布时间：2012/12/5 11:03:04
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3845R
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货号：BY-3845R
英文名称：Anti-CD168/RHAMM
中文名称：透明质酸介导细胞游走受体抗体
其他名称：CD168 antigen; HMMR; Hyaluronan mediated motility receptor; IHABP; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; RHAMM.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 82-84kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog
产品介绍：The CD168 antigen is a non-integral cell surface hyaluronan receptor ａnd intracellular protein. When hyaluronan binds to CD168, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. CD168 activation regulates various cellular processes including cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis, ａnd metastasis via both extracellular ａnd intracellular pathways. CD168 is involved in cellular transformation ａnd metastasis formation, ａnd in regulating extracellular-regulated kinase （ERK） activity. CD168 is also a subunit of the HARC complex. CD168 knockdown in human embryonic stem cells results in downregulation of several pluripotency markers, induction of early extraembryonic lineages, loss of cell viability, ａnd changes in cell cycle. Function : Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation ａnd metastasis formation, ａnd in regulating extracellular-regulated kinase （ERK） activity.Subcellular Location : Cell surface. Cytoplasm.Tissue Specificity : Expressed in breast cancer cell lines ａnd in normal breast tissue.CD168是透明质酸的受体,该蛋白与恶性肿瘤生成、浸润和转移有密切关联。其表达水平升高与肿瘤的侵袭呈正相关,是衡量肿瘤侵袭程度的重要标志。主要定位于细胞浆。
