产品展示
Cryopyrin/CIAS1/NALP3细胞凋亡诱导蛋白NALP3抗体
点击次数：231发布时间：2012/12/5 11:03:24
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-10021R
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详细内容
货号：BY-10021R
英文名称：Anti-Cryopyrin/CIAS1/NALP3
中文名称：细胞凋亡诱导蛋白NALP3抗体
其他名称：LRR ａnd PYD domains-containing protein 3; AGTAVPRL; AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like; Angiotensin/vasopressin receptor AII/AVP-like; C1orf7; Caterpiller protein 1.1; CIAS 1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; Muckle-Wells syndrome; MWS; NACHT; NACHT LRR ａnd PYD containing protein 3; NALP 3; NALP3; NALP3_HUMAN; NLRP3; PYPAF 1; PYPAF1 antibody PYRIN containing APAF1 like protein 1; PYRIN-containing APAF1-like protein 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 114kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：May function as an inducer of apoptosis. Interacts selectively with ASC ａnd this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation ａnd nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing ａnd release of IL1B ａnd IL18.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells ａnd osteoblasts. Undetectable or expressed at a lower magnitude in B- ａnd T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus ａnd ectocervix ａnd in the urothelial layer of the bladder.Similarity : Belongs to the NLRP family.Contains 1 DAPIN domain.Contains 9 LRR （leucine-rich） repeats.Contains 1 NACHT domain.
