产品展示
CBLL1/Ecadherin binding protein E7上皮钙粘附分子结合蛋白E7
点击次数：196发布时间：2012/12/5 11:14:54
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-8386R
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详细内容
货号：BY-8386R
英文名称：Anti-CBLL1/Ecadherin binding protein E7
中文名称：上皮钙粘附分子结合蛋白E7
其他名称：c-Cbl-like protein 1;CasBrM （murine） ecotropic retroviral transforming sequencelike 1;Casitas B-lineage lymphoma transforming sequence-like protein 1;Casitas B-lineage lymphoma-like 1;Casitas B-lineage lymphoma-transforming sequence-like protein 1;cbll1;E3 ubiquitin-protein ligase Hakai;Ecadherin binding protein E7;FLJ23109;HAKAI;HAKAI_HUMAN;MGC163403;OTTHUMP00000206720;OTTHUMP00000206722;OTTHUMP00000206724;RING finger protein 188;RNF188;MGC163401.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：Hu, mo, rat, chicken, dog
产品介绍：CBLL1, also known as HAKAI （meaning "destruction’ in Japanese）, or RNF188 （RING finger protein 188）, is a 491 amino acid protein that contains one C2H2-type zinc finger ａnd one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme ａnd immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with ａnd ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis ａnd disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion ａnd may also be involved in the regulation of epithelial-mesenchymal transitions.
