产品展示
COPS8信号转导蛋白亚基8抗体
点击次数：247发布时间：2012/12/5 11:21:07
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-9119R
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详细内容
货号：BY-9119R
英文名称：Anti-COPS8
中文名称：信号转导蛋白亚基8抗体
其他名称：COP9 homolog;COP9 signalosome complex subunit 8;Cops8;CSN8;CSN8_HUMAN;hCOP9;JAB1 containing signalosome subunit 8;JAB1-containing signalosome subunit 8;SGN8;Signalosome subunit 8.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Component of the COP9 signalosome complex （CSN）, a complex involved in various cellular ａnd developmental processes. The CSN complex is an essential regulator of the ubiquitin （Ubl） conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 ａnd IRF8/ICSBP, possibly via its association with CK2 ａnd PKD kinases. CSN-dependent phosphorylation of TP53 ａnd JUN promotes ａnd protects degradation by the Ubl system, respectively.Subcellular Location : Cytoplasm. Nucleus.
