产品展示
C-SKI/v-SKIC-SKI抗体
点击次数：260发布时间：2012/12/5 11:21:29
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1684R
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详细内容
货号：BY-1684R
英文名称：Anti-C-SKI/v-SKI
中文名称：C-SKI抗体
其他名称：Sloan-kettering viral oncogene homolog; Avian sarcoma viral （v ski） oncogene homolog; C oncogene; C ski; Ski oncogene; Ski oncoprotein; SKV; v ski avian sarcoma viral oncogene homolog; v ski sarcoma viral oncogene homolog; v-ski sarcoma viral oncogene homolog.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow, chk, dog
产品介绍：SKI is a nuclear protein that forms homodimers ａnd heterodimers ａnd binds to DNA to function as transcriptional activators ａnd repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, ａnd tumor suppressors. SKI inhibits transforming growth factor-beta （TGF-beta） signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.Subunit : Interacts with SMAD2, SMAD3 ａnd SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 ａnd SMAD1/2/3. Interacts with PRDM16 ａnd SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.Subcellular Location : Nucleus.Similarity : Belongs to the SKI family.SKI又称SKI、SKV，经研究发现SKI蛋白是刺激和诱发肿瘤生长导致癌症的关键蛋白质，SKI蛋白主要通过阻止TGF-β蛋白发挥作用,当TGF-β蛋白的信号传导被SKI蛋白阻断后，细胞就可能加速增值、生长，*终导致癌症发生。 有研究表明：c-ski可调节多种核因子的转录活性,参与神经系统发育、造血细胞的增殖和分化、肿瘤发生、组织再生等多种生理病理过程，更详细的作用机制还在进一步研究之中。
