本公司经销CBFA1/RUNX2，核心结合因子α1抗体（成骨特异性转录因子）Cbfα1，克隆类型为polyclonal，宿主来源是Rabbit，CBFA1/RUNX2核心结合因子α1抗体（成骨特异性转录因子）Cbfα1可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1134R
英文名称：Anti-CBFA1/RUNX2
中文名称：核心结合因子α1抗体（成骨特异性转录因子）Cbfα1
其他名称：RUNX2_HUMAN; Runt-related Transcription Factor 2; CBF alpha 1; CBFA1; CCD; CCD1; Cleidocranial dysplasia 1; Core binding factor; Core binding factor runt domain alpha subunit 1; Core binding factor subunit alpha 1; MGC120023; Oncogene AML 3; OSF 2; OSF2; OSF-2; Osteoblast specific transcription factor 2; OTTHUMP00000016533; PEA2 alpha A; PEA2aA; PEBP2 alpha A; PEBP2A1; PEBP2A2; PEBP2aA1; Polyomavirus enhancer binding protein 2 alpha A subunit; Runt domain; Runt related transcription factor 2; SL3 3 enhancer factor 1 alpha A subunit; SL3/AKV core binding factor alpha A subunit.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 57（hu）/67（mo,rat）kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog, hrs, cow, chk
产品介绍：Transcription factor involved in osteoblastic differentiation ａnd skeletal morphogenesis. Essential for the maturation of osteoblasts ａnd both intramembranous ａnd endochondral ossification. CBF binds to the core site, 5＇-PYGPYGGT-3＇, of a number of enhancers ａnd promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1（I） collagen, LCK, IL-3 ａnd GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element （OCFRE） （By similarity）. Inhibits KAT6B-dependent transcriptional activation.Function : Transcription factor involved in osteoblastic differentiation ａnd skeletal morphogenesis. Essential for the maturation of osteoblasts ａnd both intramembranous ａnd endochondral ossification. CBF binds to the core site, 5＇-PYGPYGGT-3＇, of a number of enhancers ａnd promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1（I） collagen, LCK, IL-3 ａnd GM-CSF promoters. Inhibits MYST4-dependent transcriptional activation.Subunit : Heterodimer of an alpha ａnd a beta subunit. Interacts with HIVEP3. The alpha subunit binds DNA as a monomer ａnd through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with G22P1 （Ku70） ａnd XRCC5 （Ku80）. Interacts with MYST3 ａnd MYST4.Subcellular Location : Nucleus.Tissue Specificity : Specifically expressed in osteoblasts. Post-translational modifications : Phosphorylated; probably by MAP kinases （MAPK）. Isoform 3 is phosphorylated on Ser340.DISEASE : Defects in RUNX2 are the cause of cleidocranial dysplasia （CLCD） [MIM:119600]; also known as cleidocranial dysostosis （CCD）. CLCD is an autosomal dominant skeletal disorder with high penetrance ａnd variable expressivity. It is due to defective endochondral ａnd intramembranous bone formation. Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones （additional cranial plates caused by abnormal ossification of the calvaria）, supernumerary teeth, short stature, ａnd other skeletal changes. In some cases defects in RUNX2 are exclusively associated with dental anomalies.Similarity : Contains 1 Runt domain.RUNX2又称：Cbfα1（Core-binding factor, alpha 3 subunit） 是新发现的一类调控间充质干细胞向成骨方向分化的特异性转录因子,参与骨形成,骨骼生长和发育的一类重要细胞,它起源于多能间充质干细胞,是间充质干细胞在体内的各种调控因素的调节下发育而成的。产品图片Antigen: bs-1134P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.