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CCR-2/CD192细胞表面趋化因子受体2抗体
点击次数：163发布时间：2012/12/5 11:23:41
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-0562R
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货号：BY-0562R
英文名称：Anti-CCR-2/CD192
中文名称：细胞表面趋化因子受体2抗体
其他名称：C-C Chemokine receptor 2B; C C chemokine receptor type 2; C C CKR 2; CC chemokine receptor type 2; CC CKR 2; CCCKR2; CCR 2; CCR1L; CCR2A; CCR2B; CCR5L; CD192 ; CD192 antigen; Chemokine C C motif receptor 2; Chemokine CC Motif Receptor 2; CKR 2; CKR2; CKR2A; CKR2B; CMKBR2; MCP 1 R; MCP1 RECEPTOR; MCP1R; Monocyte chemoattractant protein 1 receptor; Monocyte Chemotactic Protein 1 Receptor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 41kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, dog, hrs
产品介绍：CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins （MCP1, MCP3, MCP4） which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms ａnd has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen ａnd thymus.Subunit : Interacts with ARRB1Subcellular Location : Cell membrane; Multi-pass membrane protein.Tissue Specificity : Detected in monocyte/macrophage cell lines, but not in nonhematopoietic cell lines.Similarity : Belongs to the G-protein coupled receptor 1 family.CCR-2是属于G蛋白偶联受体一家族，参与调节白细胞的迁移和活性作用，是细胞膜蛋白，它的变异与HIV-1抵抗有关。CCR-2不仅在宫颈癌组织中表达，而且在人其他肿瘤如白血病、淋巴瘤、乳腺癌、肾B 癌、胃癌、结肠癌、肝癌和子宫癌中均有过度表达，可作为肝癌及乳腺癌诊断的标志物。产品图片Antigen: bs-0562P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
