本公司经销CD105/Endoglin，CD105抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD105/EndoglinCD105抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0579R
英文名称：Anti-CD105/Endoglin
中文名称：CD105抗体
其他名称：END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 70kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, cow, hrs, dog, pig, chk
产品介绍：CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- ａnd N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature ａnd proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 ａnd 3 with high affinity but not to TGF beta 2.Function : Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.Subunit : Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, ａnd 3 efficiently ａnd TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Endoglin is restricted to endothelial cells in all tissues except bone marrow.DISEASE : Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 （HHT1） [MIM:187300]; also known as Osler-Rendu-Weber syndrome 1 （ORW1）. HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, ａnd pulmonary （PAVM）, cerebral （CAVM） ａnd hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.细胞膜受体（Membrane Receptors） CD105（Endoglin）：CD105是一种存在于细胞表面的同源二聚体跨膜糖蛋白，是TGF-β受体复合物的组成部分，是TGF-β的附属受体，能与多种TGF-β超家族成员结合尤其与TGF-β1、TGF-β3有很高的亲和力，调节TGF-βs与其受体结合而参与信号传导，是内皮细胞增殖相关膜抗原，在培养的高增殖活性内皮细胞和许多恶性肿瘤组织血管内皮细胞中高表达，参与血管生成，但其在血管生成调节中的作用机制尚未阐明。主要用于各种恶性肿瘤组织中的血管生成的研究,产品图片Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CD105 Polyclonal Antibody, Unconjugated（bs-0579R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-CD105 Polyclonal Antibody, Unconjugated（bs-0579R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining