产品展示
CLCN2/CLC-2氯离子通道蛋白2抗体
点击次数：199发布时间：2012/12/5 11:26:22
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-6470R
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详细内容
货号：BY-6470R
英文名称：Anti-CLCN2/CLC-2
中文名称：氯离子通道蛋白2抗体
其他名称：Chloride Channel 2; Chloride channel protein 2; Chloride channel, voltage sensitive 2; CIC 2; CIC2; ClC-2; CLC2; Clcn2; CLCN2_HUMAN; ECA2; ECA3; EG13; EGI11; EGMA; EJM6; EJM8.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 99kDa
纯化方法：affinity purified by Protein A
交叉反应：hu,mo, rat, hrs, cow, pig, dog, chk. Rb
产品介绍：The family of voltage-dependent chloride channels （CLCs） regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle ａnd nerve cells, aid in organic solute transport ａnd maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 ａnd 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness ａnd renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal ａnd cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent’s disease, a renal disorder characterized by proteinuria ａnd hypercalciuria. CLC6 ａnd CLC7 are broadly expressed in several tissues including testis, kidney, brain ａnd muscle.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Ubiquitously expressed. Moderately expressed in aortic ａnd coronary vascular smooth muscle cells ａnd expressed at a low level in aortic endothelial cells.Similarity : Belongs to the chloride channel （TC 2.A.49） family. ClC-2/CLCN2 subfamily.Contains 2 CBS domains.
