本公司经销C-Mer/MERTK，c-mer原癌基因酪氨酸激酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，C-Mer/MERTKc-mer原癌基因酪氨酸激酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0548R
英文名称：Anti-C-Mer/MERTK
中文名称：c-mer原癌基因酪氨酸激酶抗体
其他名称：MerTK; proto-oncogene tyrosine kinase; Proto-oncogene tyrosine-protein kinase MER; Receptor tyrosine kinase; MGC133349; mer; MER-PEN; MER,
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 81kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The Major Facilitator Superfamily （MFS） is a large ａnd diverse group of secondary transporters that includes uniporters, symporters, ａnd antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, ａnd peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters ａnd antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. Peptide-transporters 2 [solute carrier family 15 （H+/peptide transporter）, member 2; SLC15A2; PEPT2 ; Oligopeptide transporter, kidney isoform ; Kidney H（+）/peptide cotransporter; ].Function : Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, ａnd phagocytosis of apoptotic cells （efferocytosis）. Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 ａnd induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization ａnd engulfment. Functions in the retinal pigment epithelium （RPE） as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors （TLRs）-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 ａnd SOCS3.Subunit : Interacts （upon activation） with TNK2; stimulates TNK2 autophosphorylation. Interacts （via N-terminus） with extracellular ligands LGALS3, TUB, TULP1 ａnd GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells ａnd platelets.Post-translational modifications : Autophosphorylated on Tyr-744, Tyr-748 ａnd Tyr-749 in the activation loop allowing full activity. Autophosphorylated on Tyr-867 leading to recruitment of downstream partners of the signaling cascade such as PLCG2.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type （immunoglobulin-like） domains.Contains 1 protein kinase domain.主要用于肿瘤方面的研究产品图片Antigen: bs-0548P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.