产品展示
CRF/CRH促肾上腺皮质激素释放因子抗体
点击次数：282发布时间：2012/12/5 11:36:15
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-0246R
优质供应
详细内容
货号：BY-0246R
英文名称：Anti-CRF/CRH
中文名称：促肾上腺皮质激素释放因子抗体
其他名称：Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, chk, pig, Rb
产品介绍：Corticotropin-releasing hormone （CRH） is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus （PVN） of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease ａnd autosomal recessive hypothalamic corticotropin dificiency has multiple ａnd potentially fatal metabolic consequences including hypoglycemia ａnd hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes ａnd is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation ａnd the timing of parturition ａnd delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.Subunit : Interacts （via C-terminus） with CRFR1 （via N-terminalv extracellular domain）.Subcellular Location : Secreted.Similarity : Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.CRF阳性神经元的胞体广泛分布于下丘脑的室旁核、背缝核和蓝斑核，这些区域也是去甲肾上腺素（NE）神经元与5－羟色胺（5－HT）神经元密集的区域。 CRF既具有神经递质的性质又具有神经激素的性质。CRF是联系神经系统与内分泌系统的桥梁，在情感障碍疾患如焦虑和抑郁的发病中发挥重要作用.
