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CK20细胞角蛋白20抗体
点击次数：496发布时间：2012/12/5 11:37:22
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1588R
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货号：BY-1588R
英文名称：Anti-CK20
中文名称：细胞角蛋白20抗体
其他名称：Cytokeratin 20; CK 20; CK20; Cytokeratin20; K20; Keratin 20; Keratin type I cytoskeletal 20; Keratin20; KRT 20; KRT 21; KRT20; KRT21; MGC35423; Protein IT.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 46kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Cytokeratin 20 is a type I keratin which is primarily expressed in gastric ａnd intestinal epithelium, urothelium, ａnd Merkel-cells. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells ａnd are subdivided into cytokeratins ａnd hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Their genes are clustered in a region of chromosome 17q12-q21. Cytokeratin 20 is a major cellular protein of mature enterocytes ａnd goblet cells ａnd is specifically expressed in the gastric ａnd intestinal mucosa. It is also expressed in adenocarcinomas of the colon, stomach, pancreas ａnd the bile system ａnd is present in mucinous ovarian tumors, transitional-cell ａnd Merkel-cell carcinomas. Notably, the squamous cell carcinomas ａnd adenocarcinomas of the breast, lung, ａnd endometrium, non-mucinous tumors of the ovary, ａnd small cell carcinomas lack cytokeratin 20.Subunit : Heterotetramer of two type I ａnd two type II keratins. Associates with KRT8.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa ａnd in the taste buds of lingual mucosa.Similarity : Belongs to the intermediate filament family.结构蛋白（Structural Proteins） CK-20细胞角蛋白-20主要用于肿瘤方面的研究，近年来大多用于消化系统恶性肿瘤的鉴别，主要在胞浆。
