本公司经销Phospho-CENPA （Ser7），磷酸化着丝粒蛋白A，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-CENPA （Ser7）磷酸化着丝粒蛋白A可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3066R
英文名称：Anti-Phospho-CENPA （Ser7）
中文名称：磷酸化着丝粒蛋白A
其他名称：CENP A; CENP-A; Centromere autoantigen A; Centromere protein A 17kDa; centromere protein A; centromeric protein A; Histone H3 like centromeric protein A.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 15kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, Rb
产品介绍：Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the （H3-H4）2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].Function : Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment ａnd assembly of kinetochore proteins, mitotic progression ａnd chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication ａnd cell division. The CENPA-H4 heterotetramer can bind DNA by itself （in vitro）.Subunit : Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA ａnd H4 assembled in one CENPA-H4 heterotetramer ａnd two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY ａnd H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact ａnd structurally more rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA ａnd histone H4, where HJURP interacts with the dimer formed by CENPA ａnd histone H4 ａnd prevents tetramerization of CENPA ａnd H4. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT ａnd MLF1IP/CENPU. Interacts （via CATD domain） with HJURP; the interaction is direct ａnd is required for its localization to centromeres. Interacts with CENPC, CENPN ａnd CENPT; interaction is direct. Interacts directly with herpes virus HSV-1 ICP0 protein. Part of a centromere complex consisting of CENPA, CENPT ａnd CENPW.Subcellular Location : Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width ａnd height.Tissue Specificity : Ubiquitinated （Probable）. Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.Phosphorylation of Ser-7 by AURKA ａnd AURKB during prophase is required for localization of AURKA ａnd AURKB at inner centromere ａnd is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA ａnd is maintained by AURKB. Poly-ADP-ribosylated by PARP1.Similarity : Belongs to the histone H3 family.Database links : UniProtKB/Swiss-Prot: P49450.1CENP-A可将着丝粒变成一个DNA和蛋白的复合物，而且确保着丝粒在细胞分裂中完好无损。CENP-A的存在确保了人体有几乎完全相同的染色体组。CENP-A功能失常将导致细胞分裂过程中发生染色体分离异常。CENP-A对于染色体着丝粒的位置起决定作用，因而被认为是重要的表观遗传学标记蛋白。CENP-A改变了核小体的性状，使得它变得更加坚硬。核小体是由DNA与组合蛋白八聚体构成的真核染色体的一种重复结构，核小体的组织对于基因调控极为重要。不同于染色质上的其他区域。CENP-A取代组蛋白H3形成核小体，CENP-A核小体重复拷贝形成一个特异的表观遗传区域。