本公司经销Cullin 4A，Cullin 4a蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cullin 4ACullin 4a蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3642R
英文名称：Anti-Cullin 4A
中文名称：Cullin 4a蛋白抗体
其他名称：CUL 4A; CUL4A; Cul4a protein; MGC36573; MGC64071.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 83kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, pig, cow, Rb, chk
产品介绍：Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 4a is an essential component of the SCF （SKP1-CUL1-F-box protein） E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction ａnd transcription. In the SCF complex, cul4A serves as a rigid scaffold that organizes the SKP1-F-box protein ａnd RBX1 subunits. Cul4A may also contribute to catalysis through positioning of the substrate ａnd the ubiquitinconjugating enzyme. Cul4A also interacts with RNF7 ａnd is part of a complex with TIP120A/CAND1, Cyclin E ａnd RBX1.Function : Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination ａnd subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate ａnd the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit ａnd is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX（DET1-COP1） directs ubiquitination of JUN. DCX（DDB2） directs ubiquitination of XPC. In association with RBX1, DDB1 ａnd DDB2 is required for histone H3 ａnd histone H4 ubiquitination in response to ultraviolet ａnd may be important for subsequent DNA repair. DCX（DTL） plays a role in PCNA-dependent polyubiquitination of CDT1 ａnd MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage ａnd during DNA replication. In association with DDB1 ａnd SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.Subunit : Component of multiple DCX （DDB1-CUL4-X-box） E3 ubiquitin-protein ligase complexes that seem to consist of DDB1, CUL4A or CUL4B, RBX1 ａnd a variable substrate recognition component which seems to belong to a protein family described as DCAF （Ddb1- ａnd Cul4-associated factor） or CDW （CUL4-DDB1-associated WD40-repeat） proteins. Component of the CSA complex （DCX（ERCC8） complex） containing ERCC8, RBX1, DDB1 ａnd CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome ａnd preferentially with the hyperphosphorylated form of RNA polymerase II. Component of the DCX（DET1-COP1） complex with the substrate recognition component DET1 ａnd COP1. Component of the DCX（DDB2） complex with the substrate recognition component DDB2. Component of the DCX（DTL） complex with the putative substrate recognition component DTL. Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 ａnd HOXA9. Interacts with DDB2; the interactions with DDB2 ａnd CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5 ａnd DCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barr virus BPLF1.Post-translational modifications : Neddylated. Deneddylated via its interaction with the COP9 signalosome （CSN） complex （By similarity）. Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.Similarity : Belongs to the cullin family.Cullin蛋白参与许多细胞功能的降解过程，包括细胞是否成长为成熟细胞、分裂或遭受凋亡的蛋白。cullin 4A主要调控血细胞。