本公司经销Complement C3b alpha＇ chain，补体C3b-α链抗体，克隆类型为polyclonal，宿主来源是Rabbit，Complement C3b alpha＇ chain补体C3b-α链抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4873R
英文名称：Anti-Complement C3b alpha＇ chain
中文名称：补体C3b-α链抗体
其他名称：Acylation stimulating protein cleavage product; Acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; ASP; C3 ａnd PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody C3 antibody C3a anaphylatoxin; CO3_HUMAN; Complement C3 alpha chain; Complement C3; Complement C3 beta chain; Complement C3 precursor; Complement C3b alpha chain; Complement C3c alpha＇ chain fragment 2; Complement C3c fragment; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; Complement component 3; Complement component 3 precursor; Complement component C3; Complement factor 3; CPAMD1; Plp.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 187kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：The complement factor C3 consists of an alpha ａnd a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a ａnd C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g ａnd C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells ａnd hepatocytes.Function : C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical ａnd alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability ａnd causes histamine release from mast cells ａnd basophilic leukocytes.Subcellular Location : Secreted.Tissue Specificity : Plasma.DISEASE : Defects in C3 are the cause of complement component 3 deficiency （C3D） [MIM:613779]. A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia ａnd vasculitic rashes, lupus-like syndrome ａnd membranoproliferative glomerulonephritis.Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 （ARMD9） [MIM:611378]. ARMD is a multifactorial eye disease ａnd the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein ａnd lipid that lie beneath the retinal pigment epithelium ａnd within an elastin-containing structure known as Bruch membrane.Similarity : Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain.