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phospho-CREM (Ser271 +Ser 274)磷酸化环磷酸腺苷反应元件调节蛋白抗体
点击次数：226发布时间：2012/12/5 11:45:17
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-4066R
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详细内容
货号：BY-4066R
英文名称：Anti-phospho-CREM （Ser271 +Ser 274）
中文名称：磷酸化环磷酸腺苷反应元件调节蛋白抗体
其他名称：cAMP response element modulator; cAMP responsive element modulator; hCREM 2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, chk
产品介绍：CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral ａnd cellular promoters. It is derived from a multiexonic gene that encodes both activators ａnd antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains ａnd block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.Function : Transcriptional regulator that binds the cAMP response element （CRE）, a sequence present in many viral ａnd cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis ａnd is involved in spermatid maturation.Subunit : Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34.Subcellular Location : Nucleus.Tissue Specificity : Expressed in testes （round spermatids） （at protein level）. Isoform 14 is the major activator form in testes.Post-translational modifications : Isoform 9 is ubiquitinated by CDC34 ａnd RAD6B in order to be degraded by the proteasome.Stimulated by phosphorylation.Similarity : Belongs to the bZIP family. Contains 1 bZIP domain.Contains 1 KID （kinase-inducible） domain.
