本公司经销CA153/EMA/Mucin-1 subunit alpha，乳腺癌相关抗原抗体，克隆类型为polyclonal，宿主来源是Rabbit，CA153/EMA/Mucin-1 subunit alpha乳腺癌相关抗原抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4763R
英文名称：Anti-CA153/EMA/Mucin-1 subunit alpha
中文名称：乳腺癌相关抗原抗体
其他名称：Breast carcinoma associated antigen DF3; CA 15 3; CA15-3; CA15-3 antigen; CA15.3; Carcinoma associated mucin; CD 227; CD227; CD227 antigen; DF3 antigen; EMA; Episialin; Epithelial membrane antigen; Epithelial mucin tandem repeat sequence; H23 antigen; H23AG; HGNC:7508; MAM6; MUC 1; MUC-1; Mucin 1; Mucin 1 precursor; Mucin1; Peanut reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; Tumor associated epithelial membrane antigen; Tumor associated mucin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 138kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：MUC1 is a large cell surface mucin glycoprotein expressed by most glandular ａnd ductal epithelial cells ａnd some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland ａnd some hematopoietic cells. It is expressed abundantly in lactating mammary glands ａnd overexpressed abundantly in >90% breast carcinomas ａnd metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors ａnd localize with erbB1 （EGFR） in lactating glands. The MUC1 gene contains seven exons ａnd produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons ａnd is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated ａnd alterations in glycosylation have been shown in epithelial cancer cells. Subunit : Contains 1 SEA domain.Subcellular Location : Secreted; Cell membrane. Cytoplasm. Nucleus. On EGF ａnd PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus ａnd Apical cell membrane. Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized ａnd recycled to the cell membrane. Located to microvilli ａnd to the tips of long filopodial protusions.Tissue Specificity : Expressed on the apical surface of epithelial cells, especially of airway passages, breast ａnd uterus. Also expressed in activated ａnd unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer ａnd also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.CA153为高分子糖蛋白，是乳腺癌标志物，其表达的量与乳腺癌的分化程度及雌激素受体高低有关联。近年来，很多学者研究认为：在人的很多种恶性肿瘤中都有CA15-3的不同表达。