产品展示
CYP46胆固醇24羟化酶抗体
点击次数：185发布时间：2012/12/5 11:50:27
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5051R
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详细内容
货号：BY-5051R
英文名称：Anti-CYP46
中文名称：胆固醇24羟化酶抗体
其他名称：Cholesterol 24-hydroxylase; CP46; CYP46; cytochrome P450 family 46; CP46A_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, Rb
产品介绍：The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism ａnd synthesis of cholesterol, steroids ａnd other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol ａnd able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.Function : Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Tissue Specificity : Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones ａnd lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age. Similarity : Belongs to the cytochrome P450 family.
