本公司经销CYP17，细胞色素P450 17抗体，克隆类型为polyclonal，宿主来源是Rabbit，CYP17细胞色素P450 17抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3853R
英文名称：Anti-CYP17
中文名称：细胞色素P450 17抗体
其他名称：CPT7; CYP17; CYP17A1; Cytochrome P450 17A1; CYPXVII; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII （steroid 17 alpha hydroxylase） adrenal hyperplasia ; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 57kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow, shp, pig, dog
产品介绍：Cytochrome P450 17A1 （CYP17A1） belongs to the cytochrome P450 family; it plays a role in the conversion of pregnenolone ａnd progesterone into their 17-alpha-hydroxylated products ａnd subsequently to dehydroepiandrosterone （DHEA） ａnd androstenedione. CYP17A1 also catalyzes both the 17-alpha-hydroxylation ａnd the 17,20-lyase reaction. CYP17A1 is involved in sexual development during fetal life ａnd at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 （AH5）. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Function : Conversion of pregnenolone ａnd progesterone to their 17-alpha-hydroxylated products ａnd subsequently to dehydroepiandrosterone （DHEA） ａnd androstenedione. Catalyzes both the 17-alpha-hydroxylation ａnd the 17,20-lyase reaction. Involved in sexual development during fetal life ａnd at puberty.Subcellular Location : Membrane.DISEASE : Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 （AH5） [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses ａnd short adult stature. Four clinical types: "salt wasting" （SW, the most severe type）, "simple virilizing" （SV, less severely affected patients）, with normal aldosterone biosynthesis, "non-classic form" or late onset （NC or LOAH）, ａnd "cryptic" （asymptomatic）.Similarity : Belongs to the cytochrome P450 family.