产品展示
CHRDL2乳腺肿瘤新因子1抗体
点击次数：171发布时间：2012/12/5 11:51:19
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3860R
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详细内容
货号：BY-3860R
英文名称：Anti-CHRDL2
中文名称：乳腺肿瘤新因子1抗体
其他名称：BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 62kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. Amember of the chordin family of proteins, it contains a signal peptide andthree CR （cysteine-rich repeat） domains. When expressed as a recombinantprotein it is secreted ａnd binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, ａnd osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, ａnd in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, ａnd colon tumors.CHRDL2原来主要用于乳腺癌的研究，近年来研究发现在肿瘤中也有发现，目前在肺癌，结肠肿瘤的研究中应用较多。
