本公司经销CYP7B1，胆固醇25α7羟化酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，CYP7B1胆固醇25α7羟化酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5052R
英文名称：Anti-CYP7B1
中文名称：胆固醇25α7羟化酶抗体
其他名称：25 hydroxycholesterol 7 alpha hydroxylase; CP7B; Cytochrome P450 7B1; Cytochrome P450 family 7 subfamily B polypeptide 1; Cytochrome P450 subfamily VIIB polypeptide 1; Oxysterol 7alpha hydroxylase; CP7B1_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 58kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, Rb
产品介绍：The CYP7B1 protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme is likely to play a minor role in total bile acid synthesis, ａnd may also be involved in the development of neurosteroid metabolism, atherosclerosis ａnd sex hormone synthesis, ａnd is a member of the cytochrome P450 superfamily of enzymes.Subcellular Location : Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.Tissue Specificity : Brain, testis, ovary, prostate, liver, colon, kidney, ａnd small intestine. DISEASE : Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A （SPG5A） [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness ａnd spasticity of the lower limbs. Rate of progression ａnd the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness ａnd stiffness in the legs, muscle spasms, ａnd dragging the toes when walking. In some forms of the disorder, bladder symptoms （such as incontinence） may appear, or the weakness ａnd stiffness may spread to other parts of the body. Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 （CBAS3） [MIM:613812]. Clinical features include severe cholestasis, cirrhosis ａnd liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable. Similarity : Belongs to the cytochrome P450 family.