产品展示
CYP2R1细胞色素P450 2R1抗体
点击次数：276发布时间：2012/12/5 11:52:24
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3900R
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详细内容
货号：BY-3900R
英文名称：Anti-CYP2R1
中文名称：细胞色素P450 2R1抗体
其他名称：Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 55kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog, Rb
产品介绍：CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism ａnd synthesis of cholesterol, steroids ａnd other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor.Defects in CYP2R1 are a cause of 25-hydroxyvitamin D（3） deficiency, also known as pseudovitamin D（3） deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity ａnd low levels of 25-hydroxyvitamin D.Subunit : Homodimer.Subcellular Location : Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.Tissue Specificity : Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.Similarity : Belongs to the cytochrome P450 family.
