产品展示
phospho-CREB-1(Ser142)磷酸化CREB-1抗体
点击次数：281发布时间：2012/12/5 11:53:43
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5269R
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详细内容
货号：BY-5269R
英文名称：Anti-phospho-CREB-1（Ser142）
中文名称：磷酸化CREB-1抗体
其他名称： Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 43kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, shp, cow, chk, hrs
产品介绍：The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element （CRE） palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization ａnd basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family ａnd with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP （CREB-binding protein）, which may reprecent a CREB co-activator.Subcellular Location : Nucleus.Similarity : Belongs to the bZIP family.Contains 1 bZIP domain.Contains 1 KID （kinase-inducible） domain.
