本公司经销Cullin 4B，CUL4B蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cullin 4BCUL4B蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6698R
英文名称：Anti-Cullin 4B
中文名称：CUL4B蛋白抗体
其他名称：Cullin-4B;Cullin4B; MRXHF2; MRXSC; CUL 4B; CUL4B; SFM2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 103kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase ａnd catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, ａnd is required for the proteolysis of several regulators of DNA replication including chromatin licensing ａnd DNA replication factor 1 ａnd cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].Function : Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination ａnd subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate ａnd the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 ａnd histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 ａnd may be important for DNA repair ａnd DNA replication. Required for ubiquitination of cyclin E, ａnd consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin （mTOR） pathway involved in control of cell growth, size ａnd metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function ａnd requires interaction between CUL4B ａnd MLST8.Subunit : Component of multiple DCX （DDB1-CUL4-X-box） E3 ubiquitin-protein ligase complexes that seem to be formed of DDB1, CUL4A or CUL4B, RBX1 ａnd a variable substrate recognition component which seems to belong to a protein family described as DCAF （Ddb1- ａnd Cul4-associated factor） or CDW （CUL4-DDB1-associated WD40-repeat） proteins. Component of the DCX（DTL） complex with the putative substrate recognition component DTL. Component of the DCX（DDB2） complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 ａnd TIP120A/CAND1. Interacts with RBX1 GRWD1, MLST8, SMU1, TLE2, TLE3, VPRBP, DDA1, DCAF6, DCAF17, DDB2, DCAF8, TIP120A/CAND1 ａnd TMEM113. Interacts with cyclin E ａnd with importins alpha-1 （KPNA2）, alpha-3 （KPNA4）, alpha-5 （KPNA1） ａnd beta-1 （KPNB1）. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 ａnd WDR5.Subcellular Location : Nucleus.Post-translational modifications : Neddylated. Deneddylated via its interaction with the COP9 signalosome （CSN） complex.DISEASE : Defects in CUL4B are the cause of mental retardation syndromic X-linked Cabezas type （MRXC） [MIM:300354]; also known as mental retardation syndromic X-linked type 15. A syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, ａnd abnormalities of the toes. Additional neurologic manifestations include speech delay ａnd impairment, tremor, seizures, gait ataxia, hyperactivity ａnd decreased attention span.Similarity : Belongs to the cullin family.Database links : UniProtKB/Swiss-Prot: Q13620.4