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CD105/EndoglinCD105抗体
点击次数:292发布时间:2012/12/5 12:42:05
更新日期:2024/9/5 14:43:01
所 在 地:中国大陆
产品型号:BY-6323R
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货号:BY-6323R
英文名称:Anti-CD105/Endoglin
中文名称:CD105抗体
其他名称:END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:
纯化方法:affinity purified by Protein A
交叉反应:Rb, dog, pig
产品介绍:CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.CD105(Endoglin):CD105是一种存在于细胞表面的同源二聚体跨膜糖蛋白,是TGF-β受体复合物的组成部分,是TGF-β的附属受体,能与多种TGF-β超家族成员结合尤其与TGF-β1、TGF-β3有很高的亲和力,调节TGF-βs与其受体结合而参与信号传导,是内皮细胞增殖相关膜抗原,在培养的高增殖活性内皮细胞和许多恶性肿瘤组织血管内皮细胞中高表达,参与血管生成,但其在血管生成调节中的作用机制尚未阐明。主要用于各种恶性肿瘤组织中的血管生成的研究,"