本公司经销DCTN1/Dynactin 1，动力蛋白激活蛋白1抗体，克隆类型为polyclonal，宿主来源是Rabbit，DCTN1/Dynactin 1动力蛋白激活蛋白1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6929R
英文名称：Anti-DCTN1/Dynactin 1
中文名称：动力蛋白激活蛋白1抗体
其他名称：Alternative names150 kDa dynein associated polypeptide; 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1 （p150 Glued （Drosophila） homolog）; Dynactin 1 （p150 glued homolog Drosophila）; Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; P135; p150 Glued （Drosophila） homolog; p150 glued; p150 glued homolog; p150（GLUED） DROSOPHILA HOMOLOG OF; p150-glued; p150glued.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 142kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, Rb, pig, cow
产品介绍：Required for the cytoplasmic dynein-driven retrograde movement of vesicles ａnd organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles ａnd organelles.Tissue specificity; Brain.Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B （HMN7B）; also known as progressive lower motor neuron disease （PLMND）. HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness ａnd wasting of distal muscles of the anterior tibial ａnd peroneal compartments of the legs. Later on, weakness ａnd atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis （ALS）. ALS is a neurodegenerative disorder affecting upper ａnd lower motor neurons, ａnd resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic ａnd environmental factors.Defects in DCTN1 are the cause of Perry syndrome （PERRYS）; also called parkinsonism with alveolar hypoventilation ａnd mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion ａnd marked weight loss. Parkinsonism develops later ａnd respiratory failure occurred terminally.