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Phospho-DARPP32(Thr75)磷酸化多巴胺/cAMP调节磷蛋白抗体
点击次数：317发布时间：2012/12/5 13:22:48
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3119R
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详细内容
货号：BY-3119R
英文名称：Anti-Phospho-DARPP32（Thr75）
中文名称：磷酸化多巴胺/cAMP调节磷蛋白抗体
其他名称：名PPP1R1B（phospho T75）; DARPP 32; Dopamine ａnd cAMP regulated neuronal phosphoprotein; Dopamine ａnd cAMP regulated phosphoprotein DARPP 32; Dopamine ａnd cAMP regulated phosphoprotein DARPP32; FLJ20940; IPPD; Neuronal phosphoprotein DARPP 32; PPP1R1B; Protein phosphatase 1 regulatory （inhibitor） subunit 1B; Protein phosphatase 1 regulatory subunit 1B.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 32kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, dog, cow, hrs, pig, Gpig
产品介绍：DARPP32 is expressed in medium sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic ａnd glutamatergic （NMDA） receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 ａnd phosphorylated DARPP32 is a potent protein phosphatase 1. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin ａnd dephosphorylation of phospho DARPP32, thereby reducing the phosphatase 1 inhibitory activity of DARPP32.DARPP-32通过自身不同位点的磷酸化对蛋白质磷酸化和去磷酸化过程发挥着双向调控的作用.DARRP-32在脑内存在于接受多巴胺能投射的神经元中,其磷酸化过程受多种神经递质的调控,在信号转导途径中处于中心位置,整合多种胞内信号转导,调节神经元的电学和化学性质以及动物的生理行为反应,参与多种生理功能和病理过程,包括药物成瘾、抑郁症、精神分裂症等.此外,DARPP-32在非神经系统的功能也逐渐被人们所认识. 多巴胺和cAMP调节的磷蛋白（dopamine ａnd adenosine 3＇5＇-monophosphate-regulated phospho-protein,Mr 32 kD,DARPP-32）是一个具有双重功能的独特蛋白,它既是磷酸酶（如PP-1）的抑制剂,也是蛋白激酶（如PKA）的抑制剂。产品图片Antigen: bs-3119P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
