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Phospho-Dab1 (Tyr220)磷酸化Disabled 1抗体
点击次数：279发布时间：2012/12/5 13:23:25
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3114R
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货号：BY-3114R
英文名称：Anti-Phospho-Dab1 （Tyr220）
中文名称：磷酸化Disabled 1抗体
其他名称：名Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Disabled 1 （Dab1） is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler ａnd yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects ａnd ataxia, disruption of neuronal migration, ａnd severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding （PTB） domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor （VLDLR） ａnd Apolipoprotein E Receptor 2 （ApoER2） through stimulation of Src family kinases. Src family kinase ａnd c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt （PKB） by reelin resulting in inhibition of glycogen synthase kinase 3 beta （GSK-3 beta） ａnd decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner ａnd regulates, likely indirectly, Reelin-induced signaling during neural cortex development.
