本公司经销dUTPase，脱氧尿嘧啶三磷酸核苷水解酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，dUTPase脱氧尿嘧啶三磷酸核苷水解酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1721R
英文名称：Anti-dUTPase
中文名称：脱氧尿嘧啶三磷酸核苷水解酶抗体
其他名称：名Deoxyuridine 5＇ triphosphate nucleotidohydrolase, nuclear isoform; dUTP pyrophosphatase; dUTPase; FLJ20622.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, dog, Rb
产品介绍：This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP ａnd pyrophosphate. This reaction serves two cellular purposes: providing a precursor （dUMP） for the synthesis of thymine nucleotides needed for DNA replication, ａnd limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal ａnd reincorporation of dUTP, is self-defeating ａnd leads to DNA fragmentation ａnd cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].Function : This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides ａnd it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.Subunit : Homotrimer.Subcellular Location : Isoform 2: Nucleus. Isoform 3: Mitochondrion.Tissue Specificity : Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication （at protein level）. Isoform 2 degradation coincides with the cessation of nuclear DNA replication （at protein level）.Post-translational modifications : Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.The initiator methionine is cleaved in isoform 2.Similarity : Belongs to the dUTPase family.dUTPase是机体中重要的水解酶，基本作用是把dUTP水解成dUMP和焦磷酸，不但可以提供给DNA的合成原料，还可以降低DNA突变的几率，对细胞遗传起到一定的稳定作用。