本公司经销Doublecortin，双皮质素抗体，克隆类型为polyclonal，宿主来源是Rabbit，Doublecortin双皮质素抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1269R
英文名称：Anti-Doublecortin
中文名称：双皮质素抗体
其他名称：名Doublecortex; DBCN; Dbct; DC; Doublin; Lis X; Lissencephalin X; Lissencephaly X linked; Lissencephaly X linked doublecortin; LISX; Neuronal migration protein doublecortin; SCLH; XLIS.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 49kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, dog, hrs, cow
产品介绍：Neuronal Marker Doublecortin （DCX） is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, ａnd continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 weeks, ａnd occurs at the same time that these cells begin to express, a marker for mature neurons. Due to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis. Indeed, the levels of DCX expression increase in response to exercise, which occurs in parallel with increased BrdU labelling, currently a "gold standard" in measuring neurogenesis.Function : Microtubule-associated protein required for initial steps of neuronal dispersion ａnd cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before ａnd during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration.Subunit : Interacts with tubulin.Subcellular Location : Cytoplasm. Cell projection. Note=Localizes at neurite tips.Tissue Specificity : Highly expressed in neuronal cells of fetal brain （in the majority of cells of the cortical plate, intermediate zone ａnd ventricular zone）, but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, ａnd not detected in heart, placenta, lung, liver, skeletal muscles, kidney ａnd pancreas.Post-translational modifications : Phosphorylation by MARK1, MARK2 ａnd PKA regulates its ability to bind mirotubules.DISEASE : Defects in DCX are the cause of lissencephaly X-linked type 1 （LISX1） [MIM:300067]; also called X-LIS or LIS. LISX1 is a classic lissencephaly characterized by mental retardation ａnd seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures ａnd severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as ＇doublecortex＇.Defects in DCX are the cause of subcortical band heterotopia X-linked （SBHX） [MIM:300067]; also known as double cortex or subcortical laminar heterotopia （SCLH）. SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral ａnd symmetric plates or bands of gray matter found in the central white matter between the cortex ａnd cerebral ventricles, cerebral convolutions usually appearing normal.Note=A chromosomal aberration involving DCX is found in lissencephaly. Translocation t（X;2）（q22.3;p25.1）.Similarity : Contains 2 doublecortin domains.神经细胞标志物（Neuronal Marker）