本公司经销DAT/Dopamine transporter，多巴胺转运蛋白DAT抗体，克隆类型为polyclonal，宿主来源是Rabbit，DAT/Dopamine transporter多巴胺转运蛋白DAT抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1714R
英文名称：Anti-DAT/Dopamine transporter
中文名称：多巴胺转运蛋白DAT抗体
其他名称：名DA transporter; DAT 1; DAT; DAT1; Dopamine transporter; SC6A3_HUMAN; SLC6A3; Sodium dependent dopamine transporter; Sodium-dependent dopamine transporter; Solute carrier family 6 （neurotransmitter transporter dopamine）, member 3; Solute carrier family 6 member 3; Variable number tandem repeat （VNTR）; dopamine transporter; ADAT 1; Adenosine deaminase tRNA specific 1; HADAT1; tRNA specific adenosine deaminase 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 68kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog
产品介绍：Plasmalemmal neurotransmitter transporters sequester synaptic ａnd peri synaptic transmitter into presynaptic elements. The Dopamine Transporter （DAT） is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, ａnd it is suspected to play a role in such neurologic ａnd psychiatric disorders as Parkinson＇s disease, Tourette＇s disease, schizophrenia, ａnd addiction. It is a 12 transmembrane domain transporter with the N ａnd C terminal regions located within the cytoplasm.Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.Involvement in disease:Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile （DYTPRI） . It is a neurodegenerative disorder characterized by infantile onset of parkinsonism ａnd dystonia. Other neurologic features include global developmental delay, bradikinesia ａnd pyramidal tract signs.Function : Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.Subunit : Homooligomer; disulfide-linked. Interacts with PRKCABP ａnd TGFB1I1. Interacts （via N-terminus） with SYNGR3 （via N-terminus） （By similarity）. Interacts with SLC18A2.Subcellular Location : Membrane; Multi-pass membrane protein.DISEASE : Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile （DYTPRI） [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism ａnd dystonia. Other neurologic features include global developmental delay, bradikinesia ａnd pyramidal tract signs.Similarity : Belongs to the sodium:neurotransmitter symporter （SNF） （TC 2.A.22） family. SLC6A3 subfamily.DATI 可能参与神经系统的多种活动，如学习记忆、嗅觉、感觉、运动、多巴胺神经递质活动的调节，而且可能参与胶质瘤等神经系统肿瘤的发生,阳性着色主要定位于细胞质，但也可见到有些细胞核内的阳性染色.