本公司经销DcR2/CD264/TNFRSF10D，诱捕受体2抗体，克隆类型为polyclonal，宿主来源是Rabbit，DcR2/CD264/TNFRSF10D诱捕受体2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1694R
英文名称：Anti-DcR2/CD264/TNFRSF10D
中文名称：诱捕受体2抗体
其他名称：名TNFRSF10D; Decoy receptor 2; CD 264; CD264; DcR 2; decoy with truncated death domain; ID; TNF receptor related receptor for TRAIL; TNF related apoptosis inducing ligand receptor 4; TNFRSF 10D; TRAIL R4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAILR4; TRIALR 4; TRUNDD; Tumor necrosis factor receptor superfamily member 10d decoy with truncated death domain; Tumor necrosis factor receptor superfamily member 10D precursor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Apoptosis is induced by certain cytokines including TNF ａnd Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L, a member of the TNF family, induces apoptosis of a variety of tumor cell lines. DR4 ａnd DR5 are functional receptors for TRAIL, ａnd DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was identified ａnd designated DcR2. The DcR2 receptor is 386 amino acids in length ａnd has an extracellular TRAIL binding domain, but lacks intracellular death domain ａnd does not induce apoptosis. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain ａnd functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. Like DR4 ａnd DR5, DcR2 transcript is widely expressed in a variety of normal human tissues but DcR2 is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. Over expression of DcR2 attenuated TRAIL induced apoptosis.Subcellular Location : Membrane; Single-pass type I membrane rotein.Tissue Specificity : Widely expressed, in particular in fetal kidney, lung ａnd liver, ａnd in adult testis ａnd liver. Also expressed in peripheral blood leukocytes, colon ａnd small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta ａnd heart.Similarity : Contains 1 death domain.Contains 3 TNFR-Cys repeats.DcR1因缺乏细胞内信号传导系统而不能传递凋亡信号,但能竞争性与TRAIL（肿瘤坏死因子相关凋亡诱导配体）结合,有干扰凋亡信号的传导作用。产品图片Overlay histogram showing CK-8T cells stained with bs-1694R-PE （red line）. The cells were fixed with 1% paraformaldehyde （10 min）.The cells were then incubated with the antibody （bs-1694R-PE, 2ug/1x106cells） for 30 min at 22-25°C. Isotype control antibody （black line） was rabbit IgG （2ug/1x106cells） used under the same conditions. Acquisition of events were used for analysis.