产品展示
DFF-40beta/CAD/CPANCaspase 激活的脱氧核糖核酸酶抗体
点击次数：240发布时间：2012/12/5 13:31:28
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-0043R
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详细内容
货号：BY-0043R
英文名称：Anti-DFF-40beta/CAD/CPAN
中文名称：Caspase 激活的脱氧核糖核酸酶抗体
其他名称：名DFF-40β; DFF40β;Caspase-activated deoxyribonuclease; DNA fragmentation factor, beta subunit; DNA fragmentation factor, beta polypeptide; caspase-activated DNase; DNA fragmentation factor 40 kDa subunit; DFF-40.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat
产品介绍：Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase （CAD） is a multifunctional protein that initiates ａnd regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK ａnd EGF phosphorylate CAD at threonine 456, MAPK ａnd c-myc have been found to induce over-expression of CAD.Function : Nuclease that induces DNA fragmentation ａnd chromatin condensation during apoptosis. Degrades naked DNA ａnd induces apoptotic morphology.Subunit : Heterodimer of DFFA ａnd DFFBSubcellular Location : Cytoplasm. Nucleus.Similarity : Contains 1 CIDE-N domain.
