本公司经销DAXX，死亡相关蛋白6抗体（Fas死亡区相关蛋白），克隆类型为polyclonal，宿主来源是Rabbit，DAXX死亡相关蛋白6抗体（Fas死亡区相关蛋白）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1975R
英文名称：Anti-DAXX
中文名称：死亡相关蛋白6抗体（Fas死亡区相关蛋白）
其他名称：名BING 2; BING2; DAP 6; DAP6; Death associated protein 6; Fas death domain-associated protein; Death domain associated protein 6; EAP 1; EAP1; ETS1 associated protein 1; Fas death domain associated protein; hDaxx; MGC126245; MGC126246.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 82kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, shp, Rb, dog
产品介绍：Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination ａnd enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination ａnd subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 ａnd USP7 is disrupted, resulting in increased MDM2 autoubiquitination ａnd consequently, MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway ａnd apoptosis via MAP3K5 in response to signaling from TNFRSF6 ａnd TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 ａnd MAP3K5 ａnd block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation ａnd TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML ａnd may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal ａnd activated transcription. Seems to act as a transcriptional corepressor ａnd inhibits PAX3 ａnd ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 ａnd PML, respectively.Subcellular Location : Cytoplasm. Nucleus > nucleoplasm. Nucleus > PML body. Nucleus > nucleolus. Chromosome > centromere. Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, ａnd in nucleoli. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures.Tissue Specificity : Ubiquitous.Post-translational modifications : Sumoylated.Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by HIPK1 upon glucose deprivation.Polyubiquitinated; which is promoted by CUL3 ａnd SPOP ａnd results in proteasomal degradation. Ubiquitinated by MDM2; inducing its degradation. Deubiquitinated by USP7; leading to stabilize it.Similarity : Belongs to the DAXX family.