产品展示
Dab1磷脂蛋白受体Dab1抗体
点击次数：258发布时间：2012/12/5 13:38:53
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-11547R
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详细内容
货号：BY-11547R
英文名称：Anti-Dab1
中文名称：磷脂蛋白受体Dab1抗体
其他名称：名Dab 1;Dab1;Dab-1;DAB1_HUMAN;Disabled homolog 1;Disabled homolog 1 Drosophila;Scm;Scr;Scrambler;Yot;Yotari.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chi
产品介绍：Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, ａnd it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn ａnd Abl （1）. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants （2）. Reelin is a secreted protein thought to play a role in directing migrating neurons （3）. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain （4）. Dab2 （also designated DOC-2） is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, ａnd it is thought to be a negative regulator of growth （5）.Function : Adapter molecule functioning in neural development. May regulate SIAH1 activity.Post-translational modifications : Phosphorylated on Tyr-198 ａnd Tyr-220 upon reelin induction in embryonic neurons （By similarity）. Also phosphorylated on Ser-524 independently of reelin signaling.Similarity : Contains 1 PID domain.
