产品展示
DISP2转运蛋白DISP2抗体
点击次数：272发布时间：2012/12/5 13:40:00
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-11588R
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详细内容
货号：BY-11588R
英文名称：Anti-DISP2
中文名称：转运蛋白DISP2抗体
其他名称：名DISP 2;Dispatched B;Dispatched homolog 2 （Drosophila）;Dispatched homolog 2;DISPB;DKFZp547N223;HsT16908;KIAA1742;Protein dispatched homolog 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 152kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains ａnd is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, ａnd carcinogenesis ａnd the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro ａnd its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.Subcellular Location : Membrane; Multi-pass membrane protein.
