本公司经销Desmocollin 2，桥粒糖蛋白2/桥粒糖蛋白3抗体，克隆类型为polyclonal，宿主来源是Rabbit，Desmocollin 2桥粒糖蛋白2/桥粒糖蛋白3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2983R
英文名称：Anti-Desmocollin 2
中文名称：桥粒糖蛋白2/桥粒糖蛋白3抗体
其他名称：名ARVD11; Cadherin family member 2; CDHF2; Desmocollin 3; Desmocollin3; Desmocollin-2; Desmocollin-3; Desmocollin2; Desmosomal glycoprotein II ａnd III; Desmosomal glycoprotein II; Desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DGII/III; DKFZp686I11137; DSC 2; DSC2; DSC2_HUMAN; DSC3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 84kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs
产品介绍：Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins ａnd intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning （stratification） by mediating differential adhesiveness between cells that express different isoforms. Function : Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins ａnd intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning （stratification） by mediating differential adhesiveness between cells that express different isoforms.Subunit : Interacts with DSP, PKP2 ａnd JUP.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.Tissue Specificity : In all epithelia tested ａnd heart.DISEASE : Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 （ARVD11） [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 （ARVC11）. ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, ａnd sudden death. It is clinically defined by electrocardiographic ａnd angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty ａnd fibrous elements, preferentially involve the right ventricular free wall.Similarity : Contains 5 cadherin domains.Involvement in disease：Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 （ARVD11）; also known as arrhythmogenic right ventricular cardiomyopathy 11 （ARVC11）. ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, ａnd sudden death. It is clinically defined by electrocardiographic ａnd angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty ａnd fibrous elements, preferentially involve the right ventricular free wall.