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DLK1/Delta/DLL1 (C-terminus)穿膜蛋白DLK1抗体（C端）
点击次数：244发布时间：2012/12/5 13:42:31
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-4556R
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详细内容
货号：BY-4556R
英文名称：Anti-DLK1/Delta/DLL1 （C-terminus）
中文名称：穿膜蛋白DLK1抗体（C端）
其他名称：名Delta like 1 homolog; Delta （Drosophila） like 1; Delta; Delta like 1 （Drosophila）; Delta like 1; Delta like 1; Delta-like protein 1 [Precursor]; Delta1; DLL 1; Dll1; Drosophila Delta homolog 1; AW742678; DlkI; FA1; Ly107; Peg9; pG2; pref-1; SCP1; ZOG; DL1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, shp
产品介绍：This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on ｃhr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal ａnd paternal uniparental disomy of chromosome 14 （UPD14）. This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child ａnd adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy ａnd decreased fat mass. [provided by RefSeq, Mar 2010].Subunit : Monomer.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis ａnd ovary and, to a lesser degree, in adult kidney, muscle, thymus ａnd heart.Similarity : Contains 6 EGF-like domains.穿膜蛋白DLK1又称肝癌相关基因，是表皮生长因子（EGF）家族的成员,其结构特征为蛋白的细胞外区域拥有在结构及氨基酸序列上与表皮生长因子高度同源的重复结构.DLK1可以抑制脂肪前体细胞向脂肪细胞分化,在正常神经内分泌细胞及其肿瘤细胞中表达, DLK1在神经内分泌轴中起着调控细胞生长分化的作用,同时DLK1在胚胎肝、造血干细胞及早期肌肉组织中均有表达。
