产品展示
DAB2信号转导功能磷蛋白DAB2抗体
点击次数：347发布时间：2012/12/5 13:43:41
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5999R
优质供应
详细内容
货号：BY-5999R
英文名称：Anti-DAB2
中文名称：信号转导功能磷蛋白DAB2抗体
其他名称：名DAB 2; DAB-2; Differentially expressed protein 2; Disabled （Drosophila） homolog 2 （mitogen responsive phosphoprotein）; disabled （Drosophila） homolog 2 （mitogen-responsive phosphoprotein）; Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein （Drosophila）; Disabled homolog 2 mitogen responsive phosphoprotein; disabled homolog 2 mitogen-responsive phosphoprotein （Drosophila）; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 83/59/102kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, Rb
产品介绍：This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS （a guanine nucleotide exchange factor for Ras）, via its C-terminal proline-rich sequences, ａnd may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].Dab2/DOC-2是具有信号转导功能的磷蛋白,在丝裂原信号转导途径中起作用,通过蛋白质的相互作用和蛋白磷酸化而发挥作用，Dab2还参与控制细胞生长的信号通路-发挥生长抑制效应。Dab2/DOC-2又作为胞质衔接蛋白,参与细胞内蛋白运输。在肿瘤中纯合子基因缺失时被激活,是抑癌基因的候选成员。Dab2在多种肿瘤中低或失表达,如卵巢癌,乳腺癌,绒毛膜癌和前列腺癌等,重新表达能抑制肿瘤的生长。Dab2也在胚胎的发生过程中发挥重要的作用。
