产品展示
DMTF1周期素D相互作用蛋白1抗体
点击次数：288发布时间：2012/12/5 13:54:13
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-6891R
优质供应
详细内容
货号：BY-6891R
英文名称：Anti-DMTF1
中文名称：周期素D相互作用蛋白1抗体
其他名称：名Cyclin D binding Myb like transcription factor 1;cyclin D binding myb like transcription factor 1D interacting myb like protein;Cyclin D interacting Myb like protein 1;Cyclin-D-binding Myb-like transcription factor 1;Cyclin-D-interacting Myb-like protein 1;D interacting myb like protein;DMP1;DMTF;dmtf1;DMTF1_HUMAN;hDMP1;hDMTF1;mDmp1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 84kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, cow, dog
产品介绍：Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5＇-CCCG[GT]ATGT-3＇. Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.Tissue Specificity : Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate ａnd small intestine, ａnd at higher levels in spleen, testis ａnd thymus. Expressed in multiple regions of the brain ａnd CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra ａnd subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages ａnd neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes ａnd quiescent CD34 positive cells, ａnd isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas （NSCLC） due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF ａnd p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.
